Nasal polyps often return after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). A new study validates a simple Risk Predictor Score (RPS) to identify who is most likely to experience early recurrence.
The RPS combines:
Tissue biomarkers: eosinophil cationic protein (ECP), IL-5, and anti-dsDNA IgG
Clinical factors: asthma status and pre-surgery modified Lund-Mackay radiographic score
In an independent validation group, the score predicted recurrence well (AUC = 0.76), close to the original training set (AUC = 0.89).
Patients were divided into three risk groups:
High risk → median recurrence at 38 months
Intermediate risk → median recurrence at 54 months
Low risk → median recurrence at 60 months
This validated RPS helps doctors identify high-risk patients early, potentially guiding closer follow-up, more aggressive medical therapy, or personalized treatment plans to delay or prevent polyp regrowth.
References:
https://www.jacionline.org/article/S0091-6749(25)01123-6/fulltext