Eosinophilic gastrointestinal diseases: updated nomenclature

Eosinophilic gastrointestinal (GI) diseases (EGIDs) are characterized by tissue eosinophilia and symptoms of esophageal or GI dysfunction. Eosinophilic esophagitis (EoE) diagnostic criteria are well established.

The prevalence of non-EoE EGIDs is much lower, and there are no consensus guidelines for diagnosis as of year 2022.

Particularly problematic has been variable use of the term eosinophilic gastroenteritis to describe EGIDs involving the stomach, small intestine, large intestine, or groupings of these anatomic sites.

EGID is recommended as the umbrella term for pathologic infiltration of the GI tract with eosinophils:

- EoE - Esophageal involvement alone is termed EoE
- non-EoE EGID - any other location of involvement than esophagus can be termed a non-EoE EGID

Individual involved areas of the GI tract should be named specifically, and an “Eo” abbreviation convention should be used.

Read more in JACI here:

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