Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. AD can be very challenging to manage.
AD is characterized by:
- dense cutaneous dendritic cell and T-cell infiltrates
- increased inflammatory mediators in affected tissues
- barrier defects secondary to the downregulation of differentiation proteins and lipids
AD is associated with a polarized type 2 immune axis.
However, AD is not a homogenous disease. AD may be categorized into multiple clinical phenotypes depending on the underlying molecular signature (endotype).
Read more in JACI here:
https://www.jacionline.org/article/S0091-6749(22)00834-X/fulltext
https://www.jacionline.org/article/S0091-6749(22)00186-5/fulltext
Blood endotypic signatures in atopic dermatitis
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