Dr Alexei Gonzalez @alexeigonzmd: ESID data: between 5-66% of patients with CVID will develop Lund disease; 1/4 will have ILD.
GLILD has three pathologic patterns: granulomas, lymphocytic interstitial pneumonitis, and follicular bronchiolitis. GLILD future treatment: RTX x 4 cycles followed by 18 months of AZA or MMF. GLILD: steroids are 50% ineffective - consider dual immunosuppressive therapy.
Sasha Alvarado, DO @sashaaalvarado: Elena Perez, MD: 29% of patients with CVID have autoimmune manifestations.
Lisa Forbes, MD: Whole exome sequencing is preferred, but commercial labs offer accessible PID panels, and there are many experts who are happy to collaborate with private practitioners on variants of unknown significance.
GLILD has three pathologic patterns: granulomas, lymphocytic interstitial pneumonitis, and follicular bronchiolitis. GLILD future treatment: RTX x 4 cycles followed by 18 months of AZA or MMF. GLILD: steroids are 50% ineffective - consider dual immunosuppressive therapy.
Sasha Alvarado, DO @sashaaalvarado: Elena Perez, MD: 29% of patients with CVID have autoimmune manifestations.
Lisa Forbes, MD: Whole exome sequencing is preferred, but commercial labs offer accessible PID panels, and there are many experts who are happy to collaborate with private practitioners on variants of unknown significance.