This EoE cohort from the University of Pennsylvania Health Systems had severe disease:
A retrospective electronic medical record review included 950 patients with biopsy-proven EoE. This cohort was predominantly male, white, and never-smokers who presented most commonly with:
- initial biopsy results showing 49 eosinophils per high-powered field
- serum absolute eosinophilic count of 446,000/µL
- mean total IgE level of 243 IU/mL
- 55% had impaction (of which 38% required endoscopic removal)
- 56% had strictures or fibrosis (of which 56% underwent dilatation)
Therapy used was predominantly (77%) medical only. Comorbid atopy, pollen food allergy syndrome, drug allergy, anaphylaxis, autoimmunity, and psychiatric illnesses were higher in the EoE cohort compared with the general University of Pennsylvania Health Systems population.
Adults with biopsy-proven EoE had an increased risk of pollen food allergy syndrome, anaphylaxis, and comorbid autoimmune and psychiatric conditions.