This randomized trial included 130 patients with asthma aged 10 to 50 years from Iran during a 6-month period. Vitamin D was measured before, and 4 and 6 months after the intervention. Patients were divided in 2 groups randomly. Both groups received asthma controllers (budesonide or budesonide plus formoterol) according to their stage. The intervention group received vitamin D supplementation (100,000-U bolus intramuscularly plus 50,000 U orally weekly). FEV1 was significantly better in the intervention group after 6 months. The authors concluded that vitamin D supplementation associated with asthma controllers could significantly improve FEV1 in mild to moderate persistent asthma. It takes time to work and the effect tooks months to emerge.
References:
The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Saba Arshi et al. Annals of Allergy, Asthma & Immunology, Volume 113, Issue 4, Pages 404–409, October 2014.
http://www.annallergy.org/article/S1081-1206(14)00463-3/abstract
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