Highlights of the last 10 years in immunology

The journal Nature Reviews Immunology reached its 10th anniversary and the authors of one of the top-cited articles from each year took a trip down memory lane. See the results below.


The curved leucine-rich repeat region of toll-like receptors, represented here by TLR3. Image source: Wikipedia.

Some of the advances in immunology over the past 10 years include improved understanding of:

- Toll-like receptor signalling
- immune regulation mediated by regulatory T cells
- indoleamine 2,3-dioxygenase
- myeloid-derived suppressor cells
- interleukin-10
- heterogeneity of macrophages, dendritic cells and T helper cells

We all look forward to what the next 10 years of immunology research may bring.

References:

Highlights of 10 years of immunology in Nature Reviews Immunology. Nature Reviews Immunology 11, 693-702 (October 2011) | doi:10.1038/nri3063