Stress activates the hypothalamic-pituitary-adrenal axis. Release of endogenous glucocorticoids may play a role in airway homeostasis.Chronic psychosocial stress evokes asthma exacerbations.
Animal studies suggest that social stress induces corticosteroid insensitivity. Such mechanisms amplify airway inflammation in response to infections, allergen, or irritant exposure.
References:
Social stress and asthma: The role of corticosteroid insensitivity. Haczku A, Panettieri RA Jr. J Allergy Clin Immunol. 2010 Feb 10. [Epub ahead of print]
Stress and asthma. JACI Journal Club.
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