What is IgE-Facilitated Allergen Binding (IgE-FAB)?

Example: Clinical efficacy and immune regulation with peanut oral immunotherapy. Jones SM et al. J Allergy Clin Immunol. 2009 Jul 2.

IgE-Facilitated Allergen Binding (IgE-FAB) assay is an in vitro model of facilitated allergen presentation. Omalizumab binds to Cε3 region of IgE.

The addition of serum from patients who have received SCIT inhibits allergen-IgE complex binding to CD23 on B cells. CD23, also known as Fc epsilon RII, or FcεRII, is the low affinity receptor for IgE. CD23 is present on mature B cells, activated macrophages, eosinophils, dendritic cells and platelets. http://bit.ly/C2Nrh - CD23 is the low affinity IgE receptor (FceRII). CD21 (CR2) binds EBV, HHV8, C3d, and CD23 (low affinity IgE receptor (FceRII).

IgG4 antibodies from patients who received grass SCIT inhibit IgE–FAB binding to B cells -- IgG4 inhibits IgE–FAB http://bit.ly/YwpdR

IgE-Facilitated Allergen Binding (IgE-FAB) in Science in Medicine: The Jci Textbook of Molecular Medicine By Andrew R. Marks, Ushma S. Neill:

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