Highlights of the last 10 years in immunology

The journal Nature Reviews Immunology reached its 10th anniversary and the authors of one of the top-cited articles from each year took a trip down memory lane. See the results below.

The curved leucine-rich repeat region of toll-like receptors, represented here by TLR3. Image source: Wikipedia.

Some of the advances in immunology over the past 10 years include improved understanding of:

- Toll-like receptor signalling
- immune regulation mediated by regulatory T cells
- indoleamine 2,3-dioxygenase
- myeloid-derived suppressor cells
- interleukin-10
- heterogeneity of macrophages, dendritic cells and T helper cells

We all look forward to what the next 10 years of immunology research may bring.


Highlights of 10 years of immunology in Nature Reviews Immunology. Nature Reviews Immunology 11, 693-702 (October 2011) | doi:10.1038/nri3063

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