In this study, 50 asthmatic patients were treated with 200 μg of budesonide and randomly assigned to either 10 mg of simvastatin (low dose) or placebo for 8 weeks.
Sputum eosinophils were reduced by the combined therapy with budesonide and simvastatin compared with budesonide alone.
Inhaled corticosteroids work in part by activating indoleamine 2, 3-dioxygenase (IDO) through increased IL-10 secretion. Corticosteroids activate glucocorticoid-induced TNF receptor ligand, which induces activation of p52 through the nuclear factor κB pathway (NFkB). This leads to increased transcription and activation of IDO.
Simvastatin enhanced corticosteroid-activated NFkB-induction of IDO by activating type I interferons. It also enhanced the effect of corticosteroid on IL-10 release.
A statin enhances the anti-inflammatory effect of an inhaled corticosteroid in asthma, and this was mediated through the alteration of IDO activity in macrophages.
Statins May Worsen Asthma - New Findings Contradict Earlier Studies (ACAAI, 2011).
Statins May Worsen Asthma - New Findings Contradict Earlier Studies (ACAAI, 2011).
References:
Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase. J Allergy Clin Immunol. 2010 Oct;126(4):754-762.e1.
Simvastatin provides little help for reducing steroid use in asthma. JACI Blog, 2010. http://goo.gl/7xllp
Statins associated with reduced hospitalization for asthma - Taipei Veterans Hospital, 2011.
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