Role of the T cells in asthma is still to be defined

Cytokines derived from airway epithelium, including IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), might be important drivers of T(H)2-type inflammation in asthma.

The balance between effector T(H)2 cells and suppressive regulatory T cells is skewed toward a proinflammatory T(H)2 response in atopy and asthma.

Newly discovered T-cell subsets, including T(H)17, T(H)9, and T(H)22, may play a role in asthma.

Other T cells, including natural killer T cells, gamma/delta T cells, and CD8 T cells, have also been implicated in asthma, although their importance remains to be confirmed.

T and B Cells - Naive and Memory Cell Markers (click to enlarge the image).

Strategies directed specifically at the T cells are currently being evaluated, including new forms of allergen immunotherapy.

The role of the T cell in asthma. Robinson DS. J Allergy Clin Immunol. 2010 Aug 14.
Redirecting T Cells - NEJM, 2011.

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