The balance between effector T(H)2 cells and suppressive regulatory T cells is skewed toward a proinflammatory T(H)2 response in atopy and asthma.
Newly discovered T-cell subsets, including T(H)17, T(H)9, and T(H)22, may play a role in asthma.
Other T cells, including natural killer T cells, gamma/delta T cells, and CD8 T cells, have also been implicated in asthma, although their importance remains to be confirmed.
T and B Cells - Naive and Memory Cell Markers (click to enlarge the image).
Strategies directed specifically at the T cells are currently being evaluated, including new forms of allergen immunotherapy.
The role of the T cell in asthma. Robinson DS. J Allergy Clin Immunol. 2010 Aug 14.
Redirecting T Cells - NEJM, 2011.