Activation of bradykinin-mediated B2 receptor plays an important role in angioedema associated with C1 inhibitor deficiency. Icatibant is a B2 receptor antagonist.
It is unclear if other receptors expressed on endothelial cells contribute to the release of kinins and vascular leakage in these patients. The recognition of their role may have obvious therapeutic implications.
In a new study, both B1 receptor and gC1q receptor were involved in the vascular leakage induced by hereditary and acquired angioedema plasma.
Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency. Bossi F, Fischetti F, Regoli D, Durigutto P, Frossi B, Gobeil F, Ghebrehiwet B, Peerschke EI, Cicardi M, Tedesco F. J Allergy Clin Immunol. 2009 Sep 29.
Image source: Bradykinin. Wikipedia, public domain.