Update on Seafood Allergy

From Medscape:

Prevalence data from Asia highlight seafood as a significant sensitizer in up to 40% of children and 33% of adults http://bit.ly/1vFgR4

Fish allergens can be detected in serum samples of people as early as 10 min after ingestion.

Inhaled airborne seafood allergens seem to induce sensitization and reactions. Major allergen of shellfish is the muscle protein, tropomyosin, in crustacean and mollusks.

Patients with seafood allergy are frequently reported to also have allergic reactions to mites and insects. Cross-reactivity between crustacean and HDM allergens is due to amino acid homology of these invertebrate tropomyosins.

Seafood hypersensitivity in mite sensitized individuals: is tropomyosin the only responsible allergen?

Tropomyosin does not seem to be the main allergen involved in mite-seafood sensitization in mite sensitized individuals. However, high levels of sIgE to tropomyosin seem to be related to severity of symptoms. http://goo.gl/Wj9xW

A 20-year-old man with a known dust mite-related allergic rhinitis develops rash, dyspnea, bradycardia, dizziness 30 minuts after eating oysters. What is the cause?

(A) Shigella
(B) Cholera
(C) Scrombroid
(D) Tropomyosin
(E) Parvalbumin

Answer: Tropomyosin. Shrimp Allergy in Italian Adults: Skin reactivity to house dust mite (HDM) was found 70% (Int Arch Allergy Immunol. 2011),

A puzzle: an Orthodox Jewish patient with an allergy to shellfish. How is that possible?
Seafood hypersensitivity in mite sensitized individuals: is tropomyosin the only responsible allergen? http://goo.gl/A30fZ
Exposure to cockroach is linked to high shrimp IgE with questionable clinical reactivity - food challenge is needed for diagnosis (JACI, 2011).
Shellfish allergy is a frequent, long-lasting, life-threatening disorder. As shellfish consumption increases, the number of allergic reactions to shellfish is expected to continue to rise too http://goo.gl/D2PRx
Not all shellfish "allergy" is allergy http://buff.ly/136JpPq
Image source: A steamed tail-on shrimp, Wikipedia, public domain.

1 comment:

  1. Anonymous9/07/2009

    Here's a YouTube interview of an RMIT University professor explaining how you can remove allergens from seafood, making it safe to eat: