Blood endotypic signatures in atopic dermatitis

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. AD can be very challenging to manage.

AD is characterized by:

- dense cutaneous dendritic cell and T-cell infiltrates
- increased inflammatory mediators in affected tissues
- barrier defects secondary to the downregulation of differentiation proteins and lipids

AD is associated with a polarized type 2 immune axis.

However, AD is not a homogenous disease. AD may be categorized into multiple clinical phenotypes depending on the underlying molecular signature (endotype).

Read more in JACI here:

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