How to maintain your inside garden: Microbiome, Diet, and Inflammatory Disease - Twitter summary from the 2019 WSAAI meeting

Catherine Lozupone presented on "Intersection of Microbiome, Diet, and Inflammatory Disease."

Short term dietary intervention effects on microbiome:

Diet shapes the microbiome:

You may want to match the microbiome with the type of diet you have. If you like hamburgers and fries, then you might get bacteroides rich microbiome. If you have a healthier diet, then you might get prevotella rich microbiome. Healthy gut microbiome depends on context.

Short chain fatty acids (SCFAs) are produced metabolically from microbiome on high fiber diet (plants). They work to suppress the TH2 system (allergy), and are anti-inflammatory. Only soluble fiber can be converted to SCFAs.

Fecal transplants have been successful at treating C. difficile infection. Diet appears to be related to one's risk of developing C. difficile infection. Therefore, can diet prevent C. difficile infection? Low fat diet is more protective against C. difficile infection. It works through producing less primary bile acids which is needed for C. difficile growth. Soluble fiber producing SCFAs also appears to also work at preventing C. difficile. Western diets leads to less secondary bile acids which help reduce C. difficile. This gets exaggerated when you kill off the normal microbiome when using antibiotics:

Apparently, there are companies that will sequence your gut microbiome for about 100 dollars.

This is a Twitter summary from the 2019 WSAAI meeting. This summary was compiled from the tweets posted by Matthew Bowdish @MatthewBowdish and Ray Firszt @RayFirszt, who attended the 2019 Western Society of Allergy, Asthma and Immunology (WSAAI) meeting. The tweets were labeled #WSAAI. The text was edited by me.

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