Hives are raised, itchy, red bumps (welts) on the surface of the skin. They can be caused by an allergic reaction to food, drugs, or other causes. Urticaria affects up to 20% of people at some point in their lives.
Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for patients and physicians.
This international observational study included 600 adult patients with CSU whose symptoms persisted for longer than 12 months despite treatment.
Almost 50% of patients had moderate-to-severe disease activity as reported by Urticaria Activity Score.
CSU markedly interfered with sleep and daily activities.
Angioedema in the previous 12 months was reported by 66% of enrolled patients and significantly affected health-related quality of life (HRQoL).
More than 20% of patients reported more than 1 hour per week of missed work; productivity impairment was 27%.
CSU has considerable humanistic and economic impacts. Patients with greater disease activity and with angioedema experience greater HRQoL impairments.
Urticaria (hives): what is the cause? (click to enlarge the image).
Chronic Urticaria Treatment Options in 6 Steps (click to enlarge the image). En Español.
Laboratory Diagnosis of Chronic Urticaria (click to enlarge the image).
Anti-FceR1 autoantibodies in chronic autoimmune urticaria: IgG against FceRI (receptor for IgE) (click to enlarge the image).
The Burden of Chronic Spontaneous Urticaria Is Substantial: Real‐World Evidence From ASSURE‐CSU http://buff.ly/2swQJ5d
CIU & You - Patient support website about Chronic Idiopathic Urticaria, sponsored by the makers of Xolair http://buff.ly/1zypqKg
Urticaria and angioedema. Allergy, Asthma & Clinical Immunology 2011, 7(Suppl 1):S9.
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Image source: Urticaria, Wikipedia, public domain.