Top 10 Allergy/Immunology Articles of the Year - Twitter summary from 2014 #ACAAI meeting

Top 10 A/I Articles of the Year by Mark O'Hollaren, who ended his tenure as moderator of these literature reviews:

1. Early life air pollution increases asthma risk in minority children - AJRCCM 188:309. Early-life NO2 exposure is associated with increased risk of childhood asthma in Latinos and African-Americans.

2. Mouse vs. cockroach antigen: Which is more highly assoc with poor asthma outcomes? - JACI 132: 830. In communities with both mouse and roach, mouse antigen appears more likely to be associated with poor asthma outcomes.

3. Daily intranasal fluticasone decreases children's growth velocity - JACI in Practice 2:421.Over 52 weeks, intranasal fluticasone had small decrease (0.27 cm/year) in growth velocity compared with placebo.

4. Food diversity in the first year of life decreases allergy risk - JACI 133:1056. There was an inverse association between diversity of food introduced and the subsequent development of asthma and food allergy.

5. Can you predict who will have biphasic anaphylaxis (reactions within 72 hrs without exposure to antigen)? - JACI in Practice 2:281. Biphasic anaphylaxis was associated with 1) prior anaphylaxis, 2) unknown trigger, 3) diarrhea and 4) wheezing.

6. Long-term safety and effectiveness of bronchial thermoplasty - JACI 132:1295. Data shows 5-year durability of benefit from BT with regards to asthma control and safety.

7. Are patients with asthma prone to bone loss? - Annals 4:426. Yes, asthma patients had bone loss. Even those not yet diagnosed with asthma had bone loss, authors suggested possible role for Vitamin D.

8. What percentage of kids outgrow asthma? - Pediatrics 132:e435. Only about 20% of kids outgrow their asthma by age 19.

9. Does local allergic rhinitis always evolve to systemic allergic rhinitis? - JACI 133:1026. Local allergic rhinitis is not just early allergic rhinitis, but is a separate entity with its own natural history.

10. Role for coronary mast cells during acute coronary syndrome? - Annals 112:309. One previous study has shown an association with allergen IT and a lower risk of acute MI. Endothelin-1 leads to mast cell degranulation and increased metalloproteinase-2 activity. Long-term endothelin-1 antagonist improved coronary endothelial function in patients with early atherosclerosis. Perhaps novel future CAD treatments could include a mast cell inhibitor?

This is a Twitter summary from 2014 #ACAAI meeting. The post is a part of series. See the rest here:

The Twitter summary was made possible by @MatthewBowdish

Several allergists did a great job posting updates from the 2014 meeting of the #ACAAI. I used the website “All My Tweets” to review the tweets. For comparison, here are the tweets from previous #ACAAI meetings (scroll down the page for the past years):

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