Dr James Li discussed asthma and COPD:1. Asthma Control in the US, 2008-2010 - JACI. Results suggest suboptimal asthma control with underuse of long-term controller meds, overuse of rescue medications.
2. Sputum gene expression signature of 6 biomarkers discriminated asthma inflammatory phenotypes - JACI 133; 997. Sputum gene expression discriminates between inflammatory types of asthma (eosinophilic, neutrophilic, paucigranulocytic, controls). Sputum gene expression can also predict ICS responsiveness, it may help in personalized asthma care.
3. Effect of an anti-TSLP antibody on allergen-induced asthmatic responses - NEJM 370: 2102. This is a proof of concept for a TSLP inhibitor.
4. Effect of Vitamin D3 on asthma therapy failures in adults with symptomatic asthma and lower Vitamin D levels - VIDA RCT, JAMA http://t.co/fA1gj9HWEJ. This was a negative study for the use of Vitamin D3 in these patients. Don't be too quick to recommend Vitamin D for severe asthma.
5. Should we view COPD differently after ECLIPSE? - Am J Respir Crit Care Med. 2014 May 1;189(9):1022-30. COPD is heterogeneous and variable, a decline in FEV1 is more variable than previously thought. "Reversibility" not very helpful for prognostication, walk test is more useful, comorbidities are common. From @Docallergy: 20-30% of COPD patients had allergic sensitization and had increased risk for symptoms and exacerbation.
This is a Twitter summary from 2014 #ACAAI meeting. The post is a part of series. See the rest here: http://allergynotes.blogspot.com/search/label/ACAAI
The Twitter summary was made possible by @MatthewBowdish
Several allergists did a great job posting updates from the 2014 meeting of the #ACAAI. I used the website “All My Tweets” to review the tweets. For comparison, here are the tweets from previous #ACAAI meetings (scroll down the page for the past years): http://allergynotes.blogspot.com/search/label/ACAAI