Drug allergy - top articles for November 2014

Here are my suggestions for some of the top articles about drug allergy published recently:

Fatal anaphylaxis with neuromuscular blocking agents: Obese males with cardiovascular disease on beta-blockers http://buff.ly/1iFLoM8

Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century. Drug desensitization should only be performed by allergists, trained nurses, and experienced pharmacists, since this high-risk procedure involves reintroducing allergenic medication to highly sensitized patients, with the consequent potential for severe or fatal HSRs. http://buff.ly/1knuzKI

Skin testing only with penicillin G in children with a history of penicillin allergy http://buff.ly/1gw9KNH -- Among children with a history of penicillin allergy, skin testing only with penicillin G followed by a 3-dose graded challenge to the incriminated penicillin is safe and yields a good NPV. This approach could be useful when PPL is unavailable.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are Major Cause of Drug-Induced Anaphylaxis http://buff.ly/1gz5n4C

FDA warns of rare but serious hypersensitivity reactions with over-the-counter topical acne products http://buff.ly/1lRm3of

NSAIDs are the drugs most commonly involved in hypersensitivity drug reactions. http://buff.ly/1tI92CZ

Evidence on allergy testing is best for iodinated RCM, limited for blue dyes, and insufficient for fluorescein http://buff.ly/1kV8ujV

Management of Nonimmediate Hypersensitivity Reactions to Drugs includes a dozen successive steps http://buff.ly/1tI9pO9

Overdiagnosis of vaccine allergy is a major public health problem http://buff.ly/1tI9y44

Antiviral drugs used to treat HIV and hepatitis C are common causes of delayed drug hypersensitivities http://buff.ly/1tI9Ms1

Complexity of Drug Hypersensitivity: HLA-B5701 and Abacavir, HLA-B1502 and Carbamazepine increase risk http://buff.ly/1kV9kNt

Drug Hypersensitivity: Proper identification of true DH while upholding “primum non nocere” principle is a challenge http://buff.ly/1tIaIwm



Drug allergy management in 5 steps (click to enlarge the image).

The articles were selected from Twitter @Allergy and RSS subscriptions. Some of the top allergy accounts on Twitter contributed links. I appreciate the curation provided by @Aller_MD @IgECPD @DrAnneEllis @mrathkopf.

Please feel free to send suggestions for articles to AllergyGoAway AT gmail DOT com and you will receive an acknowledgement in the next edition of this publication.

Image source: Wikipedia, GNU Free Documentation License.