Wheeze phenotypes in young children: no remission is observed in atopic multiple-trigger wheeze

This French study aimed to determine if three asthma phenotypes have different courses during the preschool period as part of the prospectively followed Trousseau Asthma Program cohort:

- early viral wheeze (EVW)
- atopic multiple-trigger wheeze (MTW)
- nonatopic uncontrolled wheeze (NAUW)

Wheeze Phenotypes in Preschool Children (click to enlarge the image):

At age 5, children with mild EVW became asymptomatic or remained with mild EVW. Those with atopic MTW remained with atopic MTW and those with NAUW developed severe wheeze in most cases.

These results show that remission is most frequently observed in mild EVW and that no remission is observed in atopic MTW.


Wheeze phenotypes in young children have different courses during the preschool period. Just J, Saint-Pierre P, Gouvis-Echraghi R, Boutin B, Panayotopoulos V, Chebahi N, Ousidhoum-Zidi A, Khau CA. Ann Allergy Asthma Immunol. 2013 Oct;111(4):256-261.e1. doi: 10.1016/j.anai.2013.07.002. Epub 2013 Jul 30.

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