Drug allergy - top articles for January 2014

Here are my suggestions for some of the top articles about drug allergy from the last few months:

Hand symptoms are closely associated with latex sensitization (11 times more likely to have positive SPT) http://buff.ly/Qk68M8

Serum sickness related to the administration of influenza vaccine http://buff.ly/YOVCVq

Successful desensitization to rosuvastatin in a patient with a history of anaphylaxis to multiple statins http://buff.ly/UubY3p

Anaphylaxis due to subcutaneously injected heparin http://buff.ly/10Gk1yO

False-Positive Results for Penicillin Allergy may occur in 26% patients with ImmunoCAP http://buff.ly/XlXIqA

Reactions to radiocontrast media probably have multiple causes - skin testing can be considered in selected patients http://buff.ly/14DSPic

ACEI−related angioedema can present as isolated swelling of the genitals - penile angioedema after 3 yrs ACEI therapy http://buff.ly/XY5dYt

Allergic anaphylaxis due to subcutaneously injected heparin http://buff.ly/10Gk1yO

Radiocontrast media skin tests for screening is of no clinical utility in predicting hypersensitivity reactions http://buff.ly/16vgUsF

Desensitization to antineoplastic agents: a new short protocol http://buff.ly/15M0KON

For many other drugs, there is insufficient evidence to recommend appropriate drug concentration for skin testing http://buff.ly/17tuG21

Multiple drug hypersensitivity syndrome (MDH) is a distinct clinical entity, different from cross-reactivity http://buff.ly/12jKvov



Classification of adverse reactions to drugs, using the "SOAP III" mnemonic (click to enlarge the image).

Allergy to sulfonamides - JACI 2012 review http://buff.ly/Uu8myd

Desensitization to antibiotics in children - 2012-Pediatric Allergy and Immunology (PDF) http://buff.ly/XlsvV5

Toxic epidermal necrolysis: the year in review. This reaction is mediated by cytotoxic T lymphocytes (CTLs) in an HLA-restricted fashion. Downstream cytotoxic signals have been elucidated with granulysin, a cytotoxic protein produced by CTLs or natural killer cells deemed to be the key mediator in the reaction. http://buff.ly/17fjVOr

The articles were selected from Twitter @Allergy and RSS subscriptions. Some of the top allergy accounts on Twitter contributed links. I appreciate the curation provided by @Aller_MD @AllergyNet @IgECPD @DrAnneEllis @AACMaven @AllergieVoeding @allergistmommy @mrathkopf @wheezemd.

Please feel free to send suggestions for articles to allergycases AT gmail DOT com and you will receive an acknowledgement in the next edition of this publication.

Image source: Wikipedia, GNU Free Documentation License.