This study analyzed longitudinal data (twice, 10 yr apart) from 3,320 adults with asthma. There were seven asthma phenotypes (prevalence range, 8.4-20.8%), characterized by the level of asthma symptoms (low, moderate, high), the allergic status, and pulmonary function.
Phenotypes observed 10 years apart showed strong similarities. The probability of membership in the same asthma phenotype at both times varied across phenotypes from 54 to 88%. Transitions toward increased asthma symptoms were more frequently observed among nonallergic phenotypes as compared with allergic phenotypes. There was a strong stability of the allergic status over time.
Adult asthma phenotypes identified by a clustering approach, 10 years apart, were highly consistent.
Ten-Year Follow-up of Cluster-based Asthma Phenotypes in Adults. A Pooled Analysis of Three Cohorts. Boudier A, Curjuric I, Basagaña X, Hazgui H, Anto JM, Bousquet J, Bridevaux PO, Dupuis-Lozeron E, Garcia-Aymerich J, Heinrich J, Janson C, Künzli N, Leynaert B, de Marco R, Rochat T, Schindler C, Varraso R, Pin I, Probst-Hensch N, Sunyer J, Kauffmann F, Siroux V. Am J Respir Crit Care Med. 2013 Sep 1;188(5):550-60. doi: 10.1164/rccm.201301-0156OC.