Anna Nowak-Wegrzyn discussed oral immunotherapy (IT) for food allergy:
The goals of food oral immunotherapy (IT) are:
- protection from anaphylaxis
- restore/induce permanent oral tolerance
There was a 1908 case report in The Lancet of oral desensitization to egg - everything old is new again!
A placebo controlled trial of peanut OIT showed a dramatic increase in threshold after 12 months (Varshney 2011).
The first DBPC trial of milk OIT showed a significant increase in threshold, and decreased skin test reactivity (Skripak 2008).
A DBPC trial of egg OIT (severe anaphylaxis excluded) (Burks 2012) consisted of 22 months therapy, followed by 4-6 weeks of avoidance: 75% of patients were desensitized, but only 28% maintained tolerance.
The most common reason for patients to stop food desensitization may not be what you think - it was GI “distress.”
A rapid milk OIT with omalizumab (16 wks of anti-IgE, 9 before starting OIT) decreased reaction frequency/severity (Nadeau 2011).
Twitter summary made possible by @allergydoc4kidz @DrAnneEllis @IgECPD4
Three allergists did a great job posting updates from the 2012 meeting of the Canadian Society of Allergy and Clinical Immunology (#CSACI): @allergydoc4kidz @DrAnneEllis @IgECPD4. Compared to year 2011, this represents 300% growth in Twitter use by the Canadian allergists. The AAAAI has a larger audience and not surprisingly 30 allergists posted Twitter updates from the 2012 #AAAAI meeting. I used the website “All My Tweets” to review the updated from each allergist, for example: http://www.allmytweets.net/#@IgECPD4
For comparison, here are the tweets from the 2011 #CSACI meeting: http://allergynotes.blogspot.com/search/label/CSACI