Drug allergy - top articles in June 2012

Here are my suggestions for some of the top articles about drug allergy in May and June 2012:

Nonirritant intradermal skin test concentrations of ciprofloxacin, clarithromycin, and rifampicin are ciprofloxacin ~0.0067 mg/ml, clarithromycin ~0.05 mg/ml, rifampicin ~0.002 mg/ml http://bit.ly/HIDJB2

The concept of "compartment allergy": prilocaine injected into different skin layers http://goo.gl/Ns6kT

Deciding on ARBs after ACE inhibitor angioedema http://goo.gl/Crvgq

SLIT for natural rubber latex (NRL) was effective and safe in children with latex allergy (study) http://goo.gl/OLhux

Hypersensitivity reactions to paracetamol (acetaminophen, Tylenol) appear to be increasing http://goo.gl/zZp9q

Diagnostic evaluation of patients with nonimmediate cutaneous hypersensitivity reactions to iodinated contrast. Patients with nonimmediate reactions to contrast media (CM) were identified by skin testing in 43.6% and by drug provocation test (DPT) in 56.4%. The method to confirm the diagnosis differed depending on the CM involved. media http://goo.gl/wmoAs|

Drug allergy to antihistamines? Here's a method for drug challenge: http://goo.gl/stXrk

Heparin allergy: what are the anticoagulant alternatives? http://goo.gl/4rTam - Substitution with argatroban would be a good choice.

The Emerging Threat of Untreatable Gonococcal Infection - what to do if allergic to PCN and cephalosporins? NEJM http://goo.gl/fwFq3

Skin testing to penicillin is an extremely safe procedure - AAAAI Ask the Expert http://goo.gl/GBhtZ

For penicillin-allergic patients, the use of third- or fourth-generation cephalosporins or cephalosporins with dissimilar side chains than the offending penicillin carries a negligible risk of cross allergy - Medscape review http://goo.gl/3tFf8

The 79 authors of WAO WHITE BOOK ON ALLERGY cover all aspects of allergic disease. I’m honored to be one of them, the book is free to download http://goo.gl/I9KwE



Classification of adverse reactions to drugs, using the "SOAP III" mnemonic (click to enlarge the image).

The articles were selected from my Twitter and Google Reader streams. Please feel free to send suggestions for articles to allergycases@gmail.com and you will receive acknowledgement in the next edition of this publication.

Image source: Wikipedia, GNU Free Documentation License.

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