Two handheld FeNO monitors - which one is better?

The use of portable fractional exhaled nitric oxide (FENO) devices is increasingly common in the diagnosis and management of allergic airways inflammation.

This study tested 2 handheld FENO devices - NIOX-MINO® and NObreath® devices - to determine if:

- there was adequate intradevice repeatability to allow the use of single breath testing
- the devices could be used interchangeably

The NIOX-MINO® showed excellent repeatability (mean difference of 0.1) (the device is shown in the illustration above). However, the NObreath® showed good repeatability (mean difference of −1.61).

Intradevice repeatability was not adequate - the NIOX-MINO® systematically produced higher results than the NObreath® (mean difference of 7.8 ppb).

The results support the manufacturer's advice that single breath testing is appropriate for the NIOX-MINO®. NObreath® results indicate that the mean of more than one breath should be utilized.

The devices cannot be used interchangeably.


Comparative repeatability of two handheld fractional exhaled nitric oxide monitors. Kirsty M. Kapande et al. Pediatr Pulmonol. 2011.

Image source: NioxMino.

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