Profilin - a pan-allergen among plants crossreacts between pollen, fruits, vegetables and latex

A 13-year-old girl who had had pollinosis (allergic rhinitis) since the age of 8 began to experience itching of the ears and vomiting after eating fresh fruits such as peach, apple and watermelon at age 10.

Cross-reactivity in Pollen-Food Allergy Syndrome (PFAS) or Oral Allergy Syndrome (OAS) (click to enlarge the image).

The girl displayed positive specific IgE reactions to 6 kinds of pollens, 11 kinds of fruits, numerous vegetables and to recombinant rBet v2.

She also reacted positively to several pollens, fruits and rBet v2 in the skin prick test.

In the component-resolved diagnosis (CRD) using microarray technology, she also tested positive for profilin, which is consired a pan-allergen among plants.

Profilin cross-reacts between pollen, fruits, vegetables and latex.

The Japanese resesearchers who reported this case concluded that the allergic reactions to multiple kinds of foods and pollens were due to cross-reactivity induced by profilin. They think that CRD by microarray is a reliable test in the diagnosis of Pollen-Food Allergy Syndrome (PFAS).


Sensitization Profiles of a Case of Pollen-Food Allergy Syndrome. Sano A, Yagami A, Inaba Y, Yamakita T, Suzuki K, Matsunaga K. Allergol Int. 2011 Jan 25;60(1).

Pollen-Food Allergy Syndrome (PFAS)

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