Metabolomics in pediatric asthma - summary from 2011 CSACI meeting

This summary was compiled from tweets posted by Dr. Stuart Carr @allergydoc4kidz, the president of the Canadian Society of Allergy and Clinical Immunology (CSACI). The tweets were labeled #CSACI and they reached more than 10,000 people. I would strongly encourage you to post updates on Twitter from the CME conferences that you are planning to attend in the future.

Darryl Adamko talked about metabolomics in pediatric asthma:

Metabolomics is the scientific study of chemical processes involving metabolites. Inflammometry is a hot topic.

Inducing sputum in kids is difficult. FeNO is promising but highly variable. Exhaled breath condensates are not well established.

There is a unique metabolic profile in atopic patient urine by NMR. The test is accessible in kids and could be practical. The computer assessment was able to very accurately predict the diagnosis of pediatric asthma based on urinary profiles in a blinded fashion.

A similar computer model was able to clearly differentiate adults with asthma from COPD in ER population. We need data on other atopic conditions (AR, AD, etc.) to see if the urine test shows asthma or simply atopy.

A 2012 study described 2 "new" phenotypes for young children with wheezing: "boys atopic multiple-trigger" and "girls nonatopic uncontrolled wheeze". JACI, 2012.

Metabolomics of Asthma - small molecules generated from cellular metabolic activity could guide diagnosis/treatment

Disclaimer: The text was edited, modified, and added to by me. I was invited to speak on the topic of social media use by the allergists during the 2011 CSACI meeting.


Dr John Weiner ‏@AllergyNet: Metabolomics in asthma. Metabolome. Metabonomics. Jeepers, I don't know. We used to call it biochemistry

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