Increasing interest has focused on whether INSs may have beneficial effects on the ocular symptoms frequently associated with AR. Steroid nose sprays improve eye symptoms of AR/AC - mechanism is unknown, but it might relate to naso-ocular reflex (http://goo.gl/VVt8k).
Treatment Options for Allergic Rhinitis (click to enlarge the image).
This meta-analysis included 10 randomized, placebo-controlled trials (3,000 patients) of the efficacy of MFNS 200 mcg daily in relieving ocular allergy symptoms, including itching/burning, redness, and tearing/watering in both SAR and PAR.
Treatment effect was significant for all three individual ocular symptoms in the SAR studies and in the PAR studies.
There is a growing body of literature supporting the positive class effect of INSs on ocular symptoms associated with SAR and PAR.
References:
Bielory L, Chun Y, Bielory BP, Canonica GW. Impact of mometasone furoate nasal spray on individual ocular symptoms of allergic rhinitis: a meta-analysis. Allergy 2011; DOI: 10.1111/j.1398-9995.2010.02543.x.
Intranasal corticosteroids had a positive impact on the eye symptoms of allergic rhinitis (review of 32 trials) http://goo.gl/EAmg1
Vernal Keratoconjunctivitis - NEJM images, 2012.
NEJM - Image Challenge http://buff.ly/1nts5dD
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