Selective serotonin reuptake inhibitors (SSRIs) do not affect the results of skin prick tests

Some drugs may cause false negative results by suppressing the reactivity of the skin prick tests (SPTs). This Turkish study aimed to show whether escitalopram, fluoxetine and sertraline had any effect on the reactivity of SPT.

24 patients who were seen at the outpatient clinic of a Psychiatry Department were included in the study.

SPTs with positive control (histamine), negative control and 3 common aeroallergens were performed in the beginning, at the first and fourth weeks.

There were no significant differences between the 3 mean diameters measured at 3 time points in addition to the mean diameters of the wheals between groups using escitalopram, sertraline and fluoxetine.

Escitalopram, fluoxetine and sertraline do not seem to affect the reactivity of SPTs.


The Effects of Antidepressants on the Results of Skin Prick Tests Used in the Diagnosis of Allergic Diseases. Isik SR, Celikel S, Karakaya G, Ulug B, Kalyoncu AF. Int Arch Allergy Immunol. 2010 Jul 27;154(1):63-68.

Effect of intranasal antihistamines on allergy skin testing - Perform a histamine skin test prior to full SPT battery.

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