Flagellin works through TLR5 as a potential vaccine adjuvant

Flagellin is a potent activator of many cell types.

Flagellin has the following properties

- adjuvant
- promoter of cytokine production
- trigger of a recruitment of T and B lymphocytes
- activates TLR5(+)CD11c(+) cells and T lymphocytes

The plasticity of flagellin has allowed for the generation of flagellin-Ag fusion proteins that are effective vaccines in animal models. The adjuvant effect of flagellin brings a lot of human research interest.


Pathogen Recognition Receptors, TLRs. This video is from: Janeway's Immunobiology, 7th Edition Murphy, Travers, & Walport. Source: Garland Science.

References:
Flagellin as an adjuvant: cellular mechanisms and potential. Mizel SB, Bates JT. J Immunol. 2010 Nov 15;185(10):5677-82.

Toll-like receptors (TLRs)