Fluticasone nasal spray relieves ocular symptoms of allergic rhinitis

Steroid nose sprays improve eye symptoms of AR/AC -  mechanism is unknown, but it might relate to naso-ocular reflex (http://goo.gl/VVt8k). Previous data suggest that intranasal fluticasone furoate (FF) improves ocular symptoms of allergic rhinitis (AR). This systematic review with meta-analysis confirmed the findings.

Primary outcomes were reflective and instantaneous total ocular symptom scores (rTOSS and iTOSS), and reflective and instantaneous total nasal symptom scores (rTNSS and iTNSS).

Secondary outcomes included the assessment of response to therapy, quality of life (QoL), and adverse effects.

16 trials (5.348 patients) were selected.

Intranasal FF improved rTOSS and iTOSS scores compared with placebo in patients with seasonal and perennial AR.

Intranasal FF showed a consistent ocular and nasal efficacy along with improvement in QoL in AR patients.

Treatment with FF nasal spray at a dose of 110 mcg once daily is effective in relieving ocular and nasal symptoms in adolescents and adults with AR.

Medications for Allergic Conjunctivitis (click to enlarge the image).

Ocular antihistamines (eye drops) (click to enlarge the image).


Efficacy of fluticasone furoate nasal spray vs. placebo for the treatment of ocular and nasal symptoms of allergic rhinitis: a systematic review. Clin Exp Allergy. 2010 Dec 1. doi: 10.1111/j.1365-2222.2010.03654.x. [Epub ahead of print]. Rodrigo GJ, Neffen H.
Vernal Keratoconjunctivitis - NEJM images, 2012.
Growth Velocity Reduced by 0.27 cm with Fluticasone Nasal Spray daily for 1 years in Prepubescent Children http://buff.ly/1jNf4Ny
Image source: OpenClipArt.org.

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