What is FOXP2?
Forkhead box protein P2, also known as FOXP2, is a protein that in humans is encoded by the FOXP2 gene, located on human chromosome 7. FOXP2 orthologs have also been identified in all mammals for which complete genome data are available.
The FOXP2 protein contains a forkhead-box DNA-binding domain, making it a member of the FOX group of transcription factors, involved in regulation of gene expression. In addition to this characteristic forkhead-box domain, the protein contains a polyglutamine tract, a zinc finger and a leucine zipper.
In humans, mutations of FOXP2 cause a severe speech and language disorder. Because of this, FOXP2 has been dubbed the "speech and language gene."
What is FOXP3?
FOXP3 (forkhead box P3) functions as the master regulator in the development and function of regulatory T cells. FOX (forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. The fork head domain is a type of protein domain which is often found in transcription factors and whose purpose is to bind DNA.
Regulatory T cells (Tregs) with transcription factor Foxp3 are the 'master regulator' population with many levels of complexity. Foxp3 is a key regulator but insufficient and unnecessary to specify all aspects of the T regs lineage. There is Treg cell diversity - distinct subphenotypes of Foxp3+ Treg cells are found in different anatomical locations http://bit.ly/3kAVQJ