368 adolescents with moderate-to-severe asthma (ages 12-20 years) living in 10 urban areas were prospectively followed for 1 year.More than 60% of female subjects and 50% of male subjects were above the 85th percentile of BMI for age. Higher BMI was associated with more symptom days and exacerbations among female subjects only.
Adiponectin was inversely related to asthma symptoms and exacerbations and positively with FEV(1)/forced vital capacity ratio in male subjects only, independent of body size.
There was no relationship between adiposity or adipokines and total IgE levels, blood eosinophil counts, and exhaled nitric oxide levels.
Adiposity is associated with poorer asthma control in female subjects. Adiponectin is associated with improved asthma control in male subjects.
Higher body mass index may decrease response to inhaled corticosteroids in persistent asthma (http://goo.gl/Xt6eP).
References:
Asthma control, adiposity, and adipokines among inner-city adolescents. Kattan M, Kumar R, Bloomberg GR, Mitchell HE, Calatroni A, Gergen PJ, Kercsmar CM, Visness CM, Matsui EC, Steinbach SF, Szefler SJ, Sorkness CA, Morgan WJ, Teach SJ, Gan VN. J Allergy Clin Immunol. 2010 Mar;125(3):584-92.
Women are more likely to be diagnosed with asthma and suffer greater morbidity than men. Medscape, 2011.
Decreased response to inhaled steroids in overweight and obese asthmatic children. JACI, 2011.
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