50% of children with soy allergy outgrew their allergy by age 7 years

Soy allergy is very common, affecting approximately 0.4% of children. It is generally thought that the majority of children with soy allergy develop tolerance in early childhood.

The records of patients with soy allergy seen in a tertiary referral clinic were reviewed and 133 patients were studied (96 male and 37 female patients):

- 64% had asthma
- 71% had allergic rhinitis
- 85% had atopic dermatitis
- 88% had concomitant peanut allergy

The median age at the initial visit was 1 year and the median duration of follow-up was 5 years.

Kaplan-Meier analysis predicted resolution of soy allergy in 25% by age 4 years, 45% by age 6 years, and 69% by age 10 years.

50% of children with soy allergy outgrew their allergy by age 7 years. Absolute soy IgE levels were useful predictors of outgrowing soy allergy.

References:
The natural history of soy allergy. Savage JH, Kaeding AJ, Matsui EC, Wood RA. J Allergy Clin Immunol. 2010 Mar;125(3):683-686.
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