SLIT with grass pollen associated with increased Foxp3 and humoral changes similar to SCIT

Foxp3+ cells were increased in the oral epithelium of SLIT- vs. placebo-treated atopics.

IgG1 and IgG4 were increased following SLIT. Peak seasonal IgA1 and IgA2 were increased during SLIT.

Efficacy of Timothy grass allergy sublingual immunotherapy tablet: 37% symptoms reduction relative to placebo http://buff.ly/1G20dYB




Pollen-producing plants (weeds and trees) in Omaha, Nebraska. V. Dimov, M.D.

References:

Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells.
http://www3.interscience.wiley.com/journal/123298968/abstract
Sublingual immunotherapy is an extremely complex issue in the U.S. - AAAAI http://goo.gl/wVOKr
Timothy grass allergy immunotherapy tablets safe and effective in American children with allergic rhinitis http://goo.gl/tsKL4
Sustained effects of grass pollen tablet: Combined symptom and medication scores demonstrated a 33% reduction, Allergy, 2011
Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults - it works. http://goo.gl/ePOFG
Sublingual grass immunotherapy (SLIT): Confirmation of disease modification 2 years after 3 years of treatment. JACI, 2012.

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