IL-22 is a member of the IL-10 cytokine family and signals through a heterodimeric receptor composed of the common IL-10R2 subunit and the IL-22R subunit. IL-10 and IL-22 both activate the STAT3 signaling pathway (STAT is Signal Transducers and Activator of Transcription).The IL-10 family includes IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26.
The IL-22 pathway has emerged as a possible target for control of inflammation in certain autoimmune diseases. The findings of this study suggest that few if any infectious complications would be expected with the suppression of IL-22 signaling.
The IL-22 pathway has emerged as a possible target for control of inflammation in certain autoimmune diseases. The findings of this study suggest that few if any infectious complications would be expected with the suppression of IL-22 signaling.
Key elements of the JAK-STAT pathway. Peter Znamenkiy, Wikipedia, public domain.
References:
Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections. Wilson MS, Feng CG, Barber DL, Yarovinsky F, Cheever AW, Sher A, Grigg M, Collins M, Fouser L, Wynn TA. J Immunol. 2010 Mar 10.
http://www.ncbi.nlm.nih.gov/pubmed/20220096
Image sources: Wikipedia, public domain.
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