CD203c is a basophil cell surface marker used to diagnose and monitor various allergic diseases.
Expression levels of CD203c were significantly higher on basophils from patients with asthma exacerbation than patients with stable asthma or healthy subjects.
In contrast, no differences in spontaneous expression levels of CD63 or CD69 were observed. The basophil activation test (BAT) relies on CD63 (tetraspanin) - a marker for flow cytometric quantification of in vitro activated basophils. CD69 - An early activation marker on T cells and NK cells.
Basophil granulocyte. Image source: Wikipedia.
Asthma exacerbation was accompanied by increased expression of CD203c on basophils that decreased significantly during remission. Basophil expression levels of CD203c might therefore be used to monitor asthma in patients.
CD203c expression on human basophils is associated with asthma exacerbation. Ono E, Taniguchi M et al. J Allergy Clin Immunol. 2010 Feb;125(2):483-489.e3.