IgE against Ara h2 can distinguish between peanut sensitization and peanut allergy

From MedPage Today:

"Standard tests" showed that 10% of eight-year-olds in a British cohort were sensitive to peanuts but only one in 50 was actually allergic when the children were challenged with the legumes.

Standard methods were defined as a skin prick test producing a wheal whose diameter was at least three millimeters greater than a negative control, and/or a IgE response of at least 0.2 kiloUnits of peanut allergen per liter of serum.

The serum immunoglobulin E (IgE ) response to a single peanut protein, dubbed Ara h 2, was able to distinguish between the sensitivity and allergy in most cases.

Avoiding peanuts only makes sense if child is really allergic.

Currently, a double-blind, placebo-controlled food challenge (DBPCFC) is the gold standard for diagnosing peanut allergy, but it's time-consuming, costly, and risks a severe reaction.

The diagnostic value of specific IgE to Ara h 2: the need for peanut challenges could be reduced by at least 50% http://buff.ly/UueEhx


Test Improves Peanut Allergy Diagnosis. MedPage Today, 2010.
Peanut allergy: Patients with a positive SPT greater than the 95% PPV do not need an Arah2 testing undertaken http://bit.ly/SwbwBQ
Peanut allergy: Diagnostic accuracy of sIgE to Ara h 6 in adults is as good as Ara h 2 http://buff.ly/1uU314i
Image source: Degranulation processes. Wikipedia, GNU Free Documentation License.

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