Allergy and Immunology News of the Day

Health News of the Day is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day.

  • Intranasal steroids (INS) downregulate increased epithelial expression of COX-1 in nasal polyps http://is.gd/hJjk

  • Children born by caesarean section have a higher risk of asthma than those born by vaginal delivery http://is.gd/hJib

  • An unusual cause of allergy: Case report of normal saline solution allergy http://www.ncbi.nlm.nih.gov..

  • Hospital disinfectants raise nurses' asthma risk http://is.gd/hQLm

  • Nurses regularly exposed to cleaning chemicals and disinfectants were 72% more likely to be newly-diagnosed with asthma http://is.gd/hQLm

Image source: OpenClipArt.org, public domain.


Allergy and Immunology News of the Day

Health News of the Day is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds (not all of them medical) that produce about 2,500 items per day.

  • Household Cleaning Aggravates Respiratory Symptoms in Women With Asthma http://tinyurl.com/dbw4az

  • "Peanut allergy assault: smearing the car door handle with peanut oil" http://tinyurl.com/d53vjh

  • Ocular olopatadine does not suppress wheal and flare during allergy skin prick testing http://tinyurl.com/cmcgn3

  • Diagnosis of bacterial sinusitis (>90%) using a test of nasal secretions (4 = protein, pH, leuk esterase, nitrite) http://tinyurl.com/aqe6vy

  • Comparison of olopatadine eye drops to nasal steroid (INS) for allergic conjunctivitis : olopatidine was better http://tinyurl.com/atdmlp

  • Compare AR nasal sprays: olopatadine to azelastine - aftertaste, patient preference, likelihood of use better with olop. http://bit.ly/tFtn

Image source: OpenClipArt.org, public domain.


Childhood peanut allergy affects mothers' quality of life more than fathers'

Peanut allergy (PA) is known to impact on quality of life (QoL) of the sufferer, but little research has focused on all family members.

46 families, who had a child with PA, completed QoL, anxiety and perceived stress (PSS) scales.

Mothers rated their own psychological and physical QoL significantly worse than fathers rated theirs. Children with PA had significantly poorer physical health-related QoL than their siblings.

Mothers report that they have significantly poorer QoL and suffer more anxiety and stress than fathers.


Eight top allergens account for 90 percent of all food allergies. See more Allergy and Immunology mind maps here.

References:
Impact of peanut allergy on quality of life, stress and anxiety in the family. King RM, Knibb RC, Hourihane JO. Allergy. 2008 Dec 4.

Increased prevalence of behavioral problems in children with asthma. http://goo.gl/qz3Bm


Breathing exercises for asthma improve patient-centred measures but not pathophysiology -- drugs still needed

A prospective, parallel group, single-blind, randomized controlled trial comparing breathing training with asthma education was performed.

Subjects with asthma with impaired health status were randomized to receive 3 sessions of either physiotherapist-supervised breathing training or asthma nurse-delivered asthma education.

The main outcome was Asthma Quality of Life Questionnaire (AQLQ) score, with secondary outcomes including spirometry, bronchial hyper-responsiveness, and exhaled nitric oxide.

Early on (one month), there was no difference but at 6 months there was a significant difference favoring breathing training.

Breathing training resulted in improvements in health status and other patient-centered measures but not in asthma pathophysiology. Exercises will not reduce the need for anti-inflammatory medication (inhaled corticosteroids).

References:
Breathing exercises for asthma: a randomised controlled trial. M Thomas et al. Thorax 2009;64:55-61.
Buteyko method, from Wikipedia, the free encyclopedia.


Statins for treatment of asthma?

Statins are widely used to treat hyperlipidemia and their immunosuppressive effect has been confirmed in immune mediated disease models.

The effect of pravastatin (shown on the right) on allergic airway inflammation in a mouse model was examined focusing on its effect on IL17 production.

Pravastatin suppresses the systemic sensitisation to allergen with downregulation of IL17 production. It also suppresses the immune response in the airway by suppressing antigen presentation in the lung.

Therefore, statins could be a novel therapeutic option for treatment of asthma.

Statins May Worsen Asthma - New Findings Contradict Earlier Studies (ACAAI, 2011).

References:
Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. M Imamura et al. Thorax 2009;64:44-49.

Simvastatin provides little help for reducing steroid use in asthma. JACI Blog, 2010. http://goo.gl/7xllp
Statins associated with reduced hospitalization for asthma - Taipei Veterans Hospital, 2011.
Image source: Simvastatin. Wikipedia, public domain.


Allergy and Immunology News of the Day

Health News of the Day is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds (not all of them medical) that produce about 2,500 items per day.

  • NYT on the hygiene hypothesis: "Babies Know: A Little Dirt Is Good for You" http://is.gd/hk2C

  • “Children should be allowed to go barefoot in the dirt, play, and not have to wash their hands when they come in to eat”

  • “Let kids have 2 dogs and a cat which will expose them to intestinal worms that can promote a healthy immune system"

Image source: OpenClipArt.org, public domain.


Allergy and Immunology News of the Day

Health News of the Day is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds (not all of them medical) that produce about 2,500 items per day.

  • 1.4 percent of all deaths around the world are caused by air pollution particles http://tinyurl.com/d299qt

  • Reduction in air pollution led to significant improvements in life expectancy (15% or 0.6 years) in the U.S. http://tinyurl.com/cjsbtl

  • Cleaner air prolongs life by 15%, 21 weeks. The bigger the decline, the longer people began living. http://tinyurl.com/d299qt

  • One-third of preschool children develop wheezing. At least 75 percent outgrow the problem by age 6. http://tinyurl.com/aameo8

  • Preemptive Fluticasone for Virus-Induced Wheezing in Children: less oral steroids needed but also less wt/ht gain http://tinyurl.com/dzfutf

  • Oral Prednisolone for Hospitalized Children with Acute Virus-Induced Wheezing: No benefit http://tinyurl.com/ae2u4s

  • Giving steroids to children hospitalized with wheezing because of viral infections does not help http://tinyurl.com/aameo8

  • "It is disturbing to contemplate how many unnecessary courses of prednisolone have been given over the years" http://tinyurl.com/aameo8

Image source: OpenClipArt.org, public domain.


Allergic asthma associated with increased FeNO, but only in never-smokers

Asthma is associated with increased FE(NO) levels.

Exhaled NO measurements were performed in 695 subjects from Turin (Italy), Gothenburg and Uppsala (both Sweden).

Allergic status was defined by using measurements of specific immunoglobulin E (IgE) (not skin prick testing).

Allergic asthma was associated with increase of FE(NO) while no significant association was found for nonallergic asthma in univariate analysis. In a multivariate analysis, both subjects with allergic asthma and nonallergic asthma had higher FE(NO) levels than nonatopic healthy subjects.

No FE(NO) increases were noted for ex- and current smokers in multivariate analysis. The findings suggest predominance of a noneosinophilic inflammation among ever-smokers.


Active and passive smoking decreased FeNO levels in adults.


Inflammation in asthma (mind map). FeNO is a marker of oxidative stress. See more Allergy and Immunology mind maps here.

References:
Both allergic and nonallergic asthma are associated with increased FE(10) levels, but only in never-smokers. Malinovschi A, Janson C, Högman M, Rolla G, Torén K, Norbäck D, Olin AC. Allergy. 2008 Dec 5.
Exhaled nitric oxide correlated with control in recurrent infantile wheeze treated with inhaled corticosteroids. http://goo.gl/AS7I
Exhaled nitric oxide (FeNO) in asthma and sinusitis. AllergyNotes.


If you think blogs don't matter, think again: this blog is the number one search result for "allergic rhinitis guidelines"


A screen shot of Google search results for "allergic rhinitis guidelines"

If you think blogs don't matter, think again: this blog is the number one search result for "allergic rhinitis guidelines." This is before the NEJM, AAFP, Medscape and AAAAI.

Things may change tomorrow, of course, but in any case it is remarkable to realize the power of the Internet created in the era of user-generated content, relevance and page rank.

Just to make it clear, I do not think that a blog provides the most reliable information on any medical topic by any stretch of the imagination. The text above only illustrates an Internet phenomenon typical of the current state of the web. It also shows why you may not be able to run a successful hospital or a medical society without a blog in the near future.

Google does not "like" static pages and neither do web users (which is all of us). Medical organizations should consider joining the dynamic web by at least having a blog and a Twitter account. This looks like the bare minimum of social network participation nowadays.


4 Pillars Of Social Media Marketing, VizEdu.com.

References:
Top U.S. Hospitals Are On Twitter
How Should Hospitals Use Twitter?
Hospitals have found Twitter. Should we be afraid? Chris Seper. MedCity News, 01/2009.


Optimal dose for 5-grass pollen sublingual tablet immunotherapy: 300 IR

628 patients with grass pollen rhinoconjunctivitis were randomized in a double-blind, placebo-controlled trial conducted in Europe.

Patients received once-daily SLIT (Stallergenes, Antony, France) of 100IR, 300IR, 500IR or placebo, starting 4 months before grass pollen season and throughout the 2005 season.

Both 300IR and 500IR doses significantly reduced mean RTSS (Rhinoconjunctivitis Total Symptom Score) compared with placebo.

Specific immunoglobulin G4 increased significantly depending on the SLIT dose.

In conclusion, 300IR tablets represent the optimal dose.


Pollen-producing plants (weeds and trees) in Omaha, Nebraska. V. Dimov, M.D.

References:
Agreement of efficacy assessments for five-grass pollen sublingual tablet immunotherapy. Allergy. 2008 Dec 5. Didier A, Melac M, Montagut A, Lhéritier-Barrand M, Tabar A, Worm M.
Talking Points on Sublingual Immunotherapy (SLIT) for Physicians Practicing in the United States. ACAAI.
Pollen Role in Allergy and Asthma. Allergy Cases, 2008.

Timothy grass allergy immunotherapy tablets safe and effective in American children with allergic rhinitis http://goo.gl/tsKL4
Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults - it works. http://goo.gl/ePOFG
Sustained effects of grass pollen tablet: Combined symptom and medication scores demonstrated a 33% reduction, Allergy, 2011.
Interactive Allergy Map by Greer Labs. Click your state to find region-specific, common airborne allergens there.
Sublingual grass immunotherapy (SLIT): Confirmation of disease modification 2 years after 3 years of treatment. JACI, 2012.


Occupational exposures (smoking + VGDF) increase risk of COPD

Data from the FLOW study of 1202 subjects with COPD and 302 controls were analyzed.

Occupational exposures were assessed using 2 methods:

1. self-reported exposure to vapors, gas, dust or fumes (VGDF) on the longest held job

2. job exposure matrix (JEM) for probability of exposure based on occupation

VGDF exposure was associated with an increased risk of COPD (OR 2.11). The risk associated with high probability of workplace exposure by JEM was similar (OR 2.27).

Joint exposure to both smoking and occupational factors markedly increased the risk of COPD (OR 14.1).

In conclusion, workplace exposures (smoking + VGDF) are strongly associated with an increased risk of COPD.

References:
Occupational exposures and the risk of COPD: dusty trades revisited. P D Blanc et al. Thorax 2009;64:6-12.
In Scotland, passage of smoke-free legislation was associated with 18% decrease in asthma hospitalizations per year http://goo.gl/6LdK
Image source: Enlarged view of lung tissue showing the difference between healthy lung and COPD, Wikipedia, public domain.


New biomarkers in asthma: chemokines and chitinase-like proteins

Asthma is characterized by airway inflammation and tissue remodeling.

Some new asthma biomarkers include:

- chemokine (C-C motif) ligand 17
- chitinase-like protein YKL-40


Chemokine (C-C motif) ligand 17. Image source: Wikipedia, public domain.

Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine that is also known as thymus and activation regulated chemokine (TARC). CCL17 binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.

References:
Novel biomarkers in asthma: chemokines and chitinase-like proteins. Mechanisms of allergy and adult asthma. Current Opinion in Allergy & Clinical Immunology. 9(1):60-66, February 2009. Hartl, Dominik; Lee, Chun G; Da Silva, Carla A; Chupp, Geoffrey L; Elias, Jack A.
CCL17, from Wikipedia, the free encyclopedia.

Biomarkers of asthma: Increased serum fibroblast growth factor, hepatocyte growth factor, stem cell growth factor-beta http://goo.gl/vsOlT


What is a sick building syndrome?

Sick building syndrome (SBS) is a combination of ailments (a syndrome) associated with an individual's place of work (office building) or residence.

A 1984 World Health Organization report suggested up to 30% of new and remodeled buildings may be linked to symptoms of SBS. Most of the sick building syndrome is related to poor indoor air quality that encourage allergenic, potentially-deadly mold growth.


Various fungi including Penicillium and Aspergillus spp. growing in axenic culture. Image source: Wikipedia, Dr. David Midgley Cultures: Dr. David Midgley University of Sydney, Australia, Creative Commons Attribution ShareAlike 2.5 License.

New studies have added evidence for the role of personality traits and psychosocial work environment, reactive chemistry and the inflammatory properties of indoor particles for SBS.

In summary, SBS is related to both personal and environmental risk factors.

References:
Sick building syndrome, from Wikipedia, the free encyclopedia.
An update on sick building syndrome. Mechanisms of allergy and adult asthma. Current Opinion in Allergy & Clinical Immunology. 9(1):55-59, February 2009. Norback, Dan.


Related:

Updated: 12/14/2009


What is the difference between hereditary angioedema (HAE) type I, II and III?

HAE type I

Autosomal dominant. 85% of the C1 esterase deficiencies. Impairment of mRNA transcription or translation which leads to decreased C1 esterase enzyme synthesis.

HAE type II

Autosomal dominant. Production of an inactive protein.

HAE type III

Estrogen-dependent -- all female. Normal C1 INH level and function and normal C4.


C1 protein, showing subunits C1r, C1s, and the C1q tails. Image source: Wikipedia.


Classical and alternative complement pathways. Image source: Wikipedia.

References:
C1 Esterase Inhibitor Deficiency. 5-Min Clinical Consult. Unbound Medicine, Inc.


Internet-based Approaches to Enhance Education of Allergy and Immunology Fellows: Practical Examples

The real-life examples listed below were collected in response to a discussion with a Residency Review Committee for Allergy and Immunology of the Accreditation Council for Graduate Medical Education (ACGME).


Remembering the ACGME 6 Core Competencies by a SIMPLE mnemonic

The Accreditation Council for Graduate Medical Education (ACGME) is responsible for the accreditation of post-MD medical training programs within the United States. The ACGME developed the so-called 6 "core competencies" that all residents should achieve during their training. When I was a chief resident, the concept was still new and not easy to remember so I made up a SIMPLE mnemonic for the 6 competencies:

SIMPLE

Systems-Based Practice
Interpersonal Skills and Communication
Medical Knowledge
Patient Care
Learning - Practice-Based and Improvement
Etiquette ~ professionalism

Let's look at each competency in detail and see how we can use Internet-based tools and service to increase the proficiency and didactic value.

PRACTICE-BASED LEARNING AND IMPROVEMENT

Examples of Learning Activities: didactic lecture, assigned reading, seminar, self-directed learning module, conference, small group discussion, workshop, online module, journal club, project, case discussion, one-on-one mentoring, or other examples of learning activities.

1. Describe one learning activity in which residents engage to identify strengths, deficiencies, and limits in their knowledge and expertise (self-reflection and self-assessment); set learning and improvement goals; identify and perform appropriate learning activities to achieve self-identified goals (life-long learning).

The residents created an online case-based curriculum of allergy and immunology (http://allergycases.org/) used to post case discussions under the guidance of faculty members. The residents were assigned articles to review for the reference section of each clinical case. The cases were used as self-directed learning modules with questions guiding the discussion through each module. An online form with question-and-answer type headlines was used to publish the clinical cases (https://spreadsheets.google.com/viewform?key=p6MskqOaqmuAtKcMX0lv7cg). The cases were discussed in small groups with direct input from a faculty member, and also on individual bases with one-on-one mentoring.

The residents were encouraged to identify strengths and deficiencies in their online presentation with each clinical case. Faculty members set learning and improvement goals by providing reference materials for further reading related to each case.

For example, a resident had questions regarding the use of immunotherapy in pregnancy. A faculty member encouraged the resident to identify the deficiencies and limits in his knowledge and expertise through guided self-reflection and self-assessment. The resident was provided verbal feedback and reference materials and encouraged to post the answers to the following questions at the learning website. The following questions were addressed: "Can immunotherapy be started if a patient is pregnant or planning to become pregnant?, Can immunotherapy be continued if the patient is on it and becomes pregnant?, What happens when the immunotherapy extract expires during pregnancy and a new vial has to be used?" (Subcutaneous Immunotherapy and Pregnancy, http://allergynotes.blogspot.com/2008/09/subcutaneous-immunotherapy-and.html).

The residents were encouraged to achieve some of the goals of life-long learning by subscribing to a specific news feed updated daily with the latest developments in the field of allergy and immunology (http://allergynotes.blogspot.com/).

In 2008, AllergyCases.org became the most popular case-based curriculum of Allergy and Immunology online ranked number one among 8.9 million pages by Google.com. The website is endorsed by both the American Academy of Allergy Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI). AllergyCases.org is supported by faculty members and fellows at Creighton University and Louisiana State University Health Sciences Center (Shreveport). It has received more than half a million page views since 2008 and has 620 daily subscribers (around 1,000 page views daily from the U.S. and around the world). The educational value of the cases is enhanced by succinct clinical notes, innovative mind maps and mnemonics. The case reports do not follow real cases and are modified in compliance with HIPAA to protect patient confidentiality. The AllergyCases.org project was presented at the 2008 and 2009 Annual Meeting of the American College of Allergy, Asthma and Immunology (ACAAI).

A poster was presented during the 2009 ACAAI meeting and published in the corresponding journal:

Dimov, V.; Randhawa, S.; Auron, M.; Casale, T. An Online Case-based Curriculum for Allergy and Immunology Education: Organization and Results. American College of Allergy, Asthma & Immunology (ACAAI) 2009 Annual Meeting. Annals of Allergy, Asthma & Immunology.

The residents used a novel communication tool available from Twitter.com to share what they learned during journal club with their peers at another allergy and immunology fellowship training program under the supervision of faculty members. This experience with a self-directed learning module was summarized in an online article (Allergy and Immunology Journal Club on Twitter, http://allergynotes.blogspot.com/2008/12/allergy-and-immunology-journal-club-on.html).

A poster was presented during the 2009 ACAAI meeting and published in the corresponding journal:

Dimov, V.; Randhawa, S.; Auron, M.; Casale, T. The Utility of a Real-time Microblogging Service for Journal Club in Allergy and Immunology. American College of Allergy, Asthma & Immunology (ACAAI) 2009 Annual Meeting. Annals of Allergy, Asthma & Immunology.

2. Describe one example of a learning activity in which residents engage to develop the skills needed to use information technology to locate, appraise, and assimilate evidence from scientific studies and apply it to their patients’ health problems. The description should include:

a) locating information
b) using information technology
c) appraising information
d) assimilating evidence information (from scientific studies)
e) applying information to patient care

Residents created an online news bulletin forum called Allergy Notes (http://allergynotes.blogspot.com/). They were encouraged to use information technology to locate and appraise evidence from scientific studies and apply it to their patients’ health problems.

For example, a resident was assigned to find the answer to the question "How prevalent is sesame allergy?" Using information technology, the resident located the related information in online databases such as Pubmed and Google Scholar which led him to specific journal articles. Under the guidance and with the direct input of a faculty member, the resident appraised and assimilated the evidence information from scientific studies. The summary was posted online to be shared with other residents and to create a permanent record for later reference (Sesame Food Allergy: Questions and Answers, http://allergynotes.blogspot.com/2008/12/sesame-food-allergy-questions-and.html). The collected information was directly applied to patient care by answering questions such as "How prevalent is sesame allergy?, What is the prevalence of sesame allergy in food allergic patients?, What is the prognosis of sesame food allergy (SFA)?, How do you diagnose sesame food allergy (SFA)?"

A poster was presented during the 2009 ACAAI meeting and published in the corresponding journal: Dimov, V.; Randhawa, S.; Auron, M.; Casale, T. The Utility of a Weblog to Stay Current with the New Developments in Allergy and Immunology. American College of Allergy, Asthma & Immunology (ACAAI) 2009 Annual Meeting. Annals of Allergy, Asthma & Immunology.

3. Give one example and the outcome of a planned quality improvement activity or project in which at least one resident participated in the past year that required the resident to demonstrate an ability to analyze, improve and change practice or patient care. Describe planning, implementation, evaluation and provisions of faculty support and supervision that guided this process.

The residents participate in an annual "weed walk" aimed at improving the recognition of common pollen-producing plants (weeds and trees) in their area. This planned quality improvement project included the attendance of all staff members (residents, faculty, nurses, research personnel).

The residents were guided through recognizing and analyzing different pollen-producing plants in the field through an one hour walk in the field. They were encouraged to take pictures of pollen-producing plants with a digital camera. The pictures were later uploaded to a photo sharing website by Google, Inc. (Picasa Web Albums, Pollen-producing plants (weeds and trees) in Omaha, Nebraska, http://picasaweb.google.com/seeomaha/PollenProducingPlantsWeedsAndTreesInOmahaNebraska#) and the residents labeled each plant under the guidance of faculty members. This pollen-recognition project was used to improve and change practice or patient care with faculty support and supervision that guided this process.

A poster was presented during the 2009 ACAAI meeting and published in the corresponding journal:

Dimov, V.; Randhawa, S.; Auron, M.; Casale, T. Digital Image Sharing Web Service for Recognition of Pollen-producing Plants in a Specific Geographic Region. American College of Allergy, Asthma & Immunology (ACAAI) 2009 Annual Meeting. Annals of Allergy, Asthma & Immunology.

4. Describe how residents:

a) develop teaching skills necessary to educate patients, families, students, and other residents;
b) teach patients, families, and others; and
c) receive and incorporate formative evaluation feedback into daily practice. (If a specific tool is used to evaluate these skills have it available for review by the site visitor).

The residents are actively encouraged to develop teaching skills necessary to educate patients, families, students, and other residents. All residents worked together to identify useful links for
Patient Information on Topics in Allergy and Immunology and they were published online as a combined list for later referral (Patient Information on Topics in Allergy and Immunology, http://allergynotes.blogspot.com/2008/03/patient-information-on-topics-in.html). The purpose of the exercise was to develop a selection of high-quality links that can be used later to print patient information when requested by patients or health workers.

For example, a patient with hereditary angioedema (HAE) had a question about a newly-approved medication to treat her condition. Under the guidance of a faculty member, the resident was able to identify the FDA source of the approval information published just a few weeks ago and to print a patient information sheet. In addition, a diagram developed several month prior to the patient encounter was identified from the learning repository (http://allergynotes.blogspot.com/), printed and used to explain the place of the new therapy in the current management concept. The whole experience was summarized in an online article for later reference (C1 Inhibitor Cinryze Approved by FDA for Prophylaxis Against Hereditary Angioedema Attacks, http://allergynotes.blogspot.com/2008/12/c1-inhibitor-cinryze-approved-by-fda.html). The educational process was associated with evaluation feedback by the faculty.

INTERPERSONAL AND COMMUNICATION SKILLS

1. Describe one learning activity in which residents develop competence in communicating effectively with patients and families across a broad range of socioeconomic and cultural backgrounds, and with physicians, other health professionals, and health related agencies.

A patient and his family had a question about the price of the new HFA albuterol inhalers. Under the guidance of a faculty member, the residents were encouraged to discuss the management and financial concerns with the family in order to identify the best solution to their problems. The socioeconomic and cultural backgrounds were identified and discussed. The residents used a novel communication tool by Twitter.com to exchange information with other residents and faculty members across the country. A past ACAAI president provided a link to a newly-available $9 Albuterol Inhaler at WalMart which proved to be the most cost effective solution for this particular patient. This example of developing competence in communicating effectively with patients and families, and with physicians, other health professionals, and health related agencies was summarized in an online article (A/I Twitter Updates: $9 Albuterol Inhaler at WalMart and More, http://allergynotes.blogspot.com/2008/12/ai-twitter-updates-9-albuterol-inhaler.html).

2. Describe one learning activity in which residents develop their skills and habits to work effectively as a member or leader of a health care team or other professional group. In the example, identify the members of the team, responsibilities of the team members, and how team members communicate to accomplish responsibilities.

The residents were encouraged to develop their skills to work effectively as a member or leader of a health care team or a group by establishing and participating in an online learning group comprised of former and current allergy and immunology fellows and faculty member. The residents used the social network platform of Facebook.com to create an online group with a team leader, officers, and community liaisons (Creighton Allergy and Immunology Fellowship Faculty, Alumni, and Friends, http://www.facebook.com/group.php?gid=30823727886). The group was used to discuss clinical and research issues in strict compliance with HIPAA. A faculty moderator was also included in this initiative to guide members to communicate effectively, delegate and accomplish responsibilities.

The resident were also encouraged to join the official Facebook group of the American College of Allergy, Asthma & Immunology (ACAAI) and to apply for team and leadership roles in the professional network (American College of Allergy, Asthma & Immunology, http://www.facebook.com/groups.php?ref=sb#/group.php?gid=25896029508).

A poster was presented during the 2009 ACAAI meeting and published in the corresponding journal:

Dimov, V.; Parks, K.; Stokes, J.; Casale, T. The Utility of an Online Social Network Service for Professional Collaboration and Education in Allergy and Immunology. American College of Allergy, Asthma & Immunology (ACAAI) 2009 Annual Meeting. Annals of Allergy, Asthma & Immunology.

VI. SYSTEMS-BASED PRACTICE

1. Describe the learning activities through which residents will achieve competence in the elements of systems-based practice. Examples of such activities would include: work effectively in various health care delivery settings and systems, coordinate patient care within the health care system; incorporate considerations of cost-containment and risk-benefit analysis in patient care; advocate for quality patient care and optimal patient care systems; and work in interprofessional teams to enhance patient safety and care quality.

The residents attending the annual meeting of the American College of Allergy, Asthma & Immunology (ACAAI) in November 2008 focused specifically on incorporating considerations of cost-containment and risk-benefit analysis in the care of patients with severe asthma. Several management approaches to decrease the frequency of exacerbations and hospitalizations were discussed during a seminar workshop. The main teaching points were shared system-wide via a communication tool provided by Twitter.com. The learning experience was shared with the other members of the team via email and summarized in an online publication for later referral (Twitter Updates from the Severe Asthma Workshop at the 2008 Annual Meeting of American College of Allergy, Asthma & Immunology (ACAAI), http://casesblog.blogspot.com/2008/11/twitter-updates-from-severe-asthma.html).

The residents are planning to use Twitter.com to share updates from the upcoming ACAAI and AAAAI meetings to share new developments aimed at enhancing patient safety and care quality with interprofessional teams (Using Twitter to Microblog a CME Meeting, http://casesblog.blogspot.com/2008/10/using-twitter-to-microblog-cme-meeting.html).

Another initiative is to enhance the team communication in a system-based practice environment by using Qik.com and other "stream video from your phone" services to share updates and gather feedback from future scientific meetings focused on health care delivery systems and coordinating patient care within the health care system (Health workers usingQik or other "stream video from your phone" services for medical education, http://casesblog.blogspot.com/2009/01/any-health-workers-using-qik-or-other.html).

Updated: 04/04/2010


Acupuncture for treatment of allergic rhinitis

Acupuncture and Chinese herbal medicine are being used increasingly for the management of allergic rhinitis.

Study 1

In a 2002 Australian study, 30 subjects were randomly assigned to two groups and treated with real or sham acupuncture (three times per week) for four consecutive weeks and then a crossover for treatments for a further four weeks without a washout period.

There was a significant improvement in five-point scale (FPS) between the two types of acupuncture treatments. The results indicate that acupuncture is an effective and safe alternative treatment for the management of SAR.

Study 2

Eighty-five patients were recruited from the pediatric outpatient clinic at Kwong Wah Hospital, in Hong Kong and randomized to receive active acupuncture for 8 weeks or sham acupuncture for 8 weeks (twice per week for both groups).

There were significantly lower daily rhinitis scores and more symptom-free days for the group receiving active acupuncture, during both the treatment and follow-up periods.

This study showed that active acupuncture was more effective than sham acupuncture in decreasing the symptom scores for persistent allergic rhinitis and increasing the symptom-free days.

Study 3

In a German study, 52 patients between the ages of 20 and 58 who had typical symptoms of seasonal AR were assigned randomly and in a blinded fashion to (i) an active treatment group which received a semi-standardized treatment of acupuncture and Chinese herbal medicine, and (ii) a control group which received acupuncture applied to non-acupuncture points in addition to a non-specific Chinese herbal formula.

The change in severity of hay fever symptoms was the primary outcome measured on a visual analogue scale (VAS).

Patients in the active treatment group showed a significant after-treatment improvement on the VAS (P = 0.006) and Rhinitis Quality of Life Questionnaire (P = 0.015).

Conclusion

Confirmatory evidence is needed from large prospective randomized multi-centre trials.

References:
Effect of acupuncture in the treatment of seasonal allergic rhinitis: a randomized controlled clinical trial. Xue CC, English R, Zhang JJ, Da Costa C, Li CG. Am J Chin Med. 2002;30(1):1-11.
Does acupuncture or Chinese herbal medicine have a role in the treatment of allergic rhinitis? Curr Opin Allergy Clin Immunol. Xue CC, Li CG, Hügel HM, Story DF. 2006 Jun;6(3):175-9.
A double-blind, randomized, placebo-controlled trial of acupuncture for the treatment of childhood persistent allergic rhinitis. Ng DK, Chow PY, Ming SP, Hong SH, Lau S, Tse D, Kwong WK, Wong MF, Wong WH, Fu YM, Kwok KL, Li H, Ho JC. Pediatrics. 2004 Nov;114(5):1242-7.
Acupuncture and Chinese herbal medicine in the treatment of patients with seasonal allergic rhinitis: a randomized-controlled clinical trial. Brinkhaus B, Hummelsberger J, Kohnen R, Seufert J, Hempen CH, Leonhardy H, Nögel R, Joos S, Hahn E, Schuppan D. Allergy. 2004 Sep;59(9):953-60.
The Recent History of Acupuncture. Edzard Ernst, MD. Am Journal of Medicine, Volume 121, Issue 12, Pages 1027-1028 (December 2008).

Allergy Sufferers Turn To Alternative Treatments - Acupuncture - WLKY Louisville.
Acupuncture from Wikipedia, the free encyclopedia.
Image source: Needles being inserted into a patient's skin, Wikipedia, public domain.


Oral immunotherapy with drinking milk may help milk allergy

According to Reuters, "giving milk-allergic children milk in increasingly higher doses over time eased their allergic reactions to milk and even helped some of the children completely overcome their milk allergy.

Oral immunotherapy may be the closest thing yet to a 'true' treatment for food allergy."

What is the prognosis in milk allergy?

Milk allergy usually occurs within the first year of life, and 60 to 75% of children undergo remission by age 2 years. By age 3 years, 85-90% can tolerate milk. Approximately 68% of milk-allergic children can tolerate extensively heated milk.


30-50% of infants allergic to cow milk protein will also be allergic to soy protein. These infants should be given protein hydrolysate formula. 5% of infants with hypersensitivity to cow milk formula will also react to hydrolysate formula and will require elemental formula.

Hydrolysate formulas are enzymatically hydrolyzed and contain charcoal-treated casein or whey. Whey or "milk plasma" is the liquid remaining after milk has been curdled and strained.

What is the most common food allergen in children?

(A) Gal d (egg)
(B) Tri a 19 (wheat)
(C) Mal d 1 (apple)
(D) Gly m (soy)
(E) Ara h (peanut)
(F) Bos d (milk)
(G) Api g 4 (celery)

Answer: F.

References:
Drinking milk may ease milk allergy. Reuters, Nov 10, 2008; Journal of Allergy and Clinical Immunology, online October 28, 2008.
Children with milk allergy tolerate heated milk
Talking Points on Sublingual Immunotherapy (SLIT) for Physicians Practicing in the United States. ACAAI.
Child with perioral rash upon milk ingestion; prognosis. Ask the Expert. AAAAI, 2009.\
Any formula use in the first 6 months of life is associated with increased incidence of otitis media http://goo.gl/LAEJ
Office-based oral immunotherapy for food allergy is safe and effective - according to Texas allergist group that use it http://goo.gl/S4N8W
Frequent otitis media during infancy linked to atopic dermaitis and asthma in later life. Medscape, 2010.
Sublingual and oral immunotherapy for milk allergy. Desensitization was lost in some cases within 1 week off therapy. JACI, 2011.
Eosinophilic esophagitis after specific oral tolerance induction for egg protein http://goo.gl/fzmip
Image source: Wikipedia, GNU Free Documentation License.


Influenza vaccination in egg allergy


CDC video: Why Flu Vaccination Matters: Personal Stories from Families Affected by Flu.

Evidence supports the relatively safe administration of influenza vaccine to individuals with egg allergy when specific protocols are followed.


Egg-allergic patients without anaphylaxis to egg may safely receive the influenza vaccine in a 2-dose, graded fashion without a vaccine skin test. Safety of Influenza Vaccine Administration in Egg-Allergic Patients. Pediatrics, Vol. 125 No. 5 May 2010, pp. e1024-e1030.

Most children with milk and egg allergy tolerate extensively heated forms of these foods http://goo.gl/Buwu

References:
Current issues with influenza vaccination in egg allergy. Robert S. Zeige. J Allergy Clin Immunol, Volume 110, Issue 6, Pages 834-840 (December 2002).
Recommendations for the administration of influenza vaccine in children allergic to egg. BMJ Clinical Review, 09/2009.
Administration of influenza vaccine to a child with a possible history of egg allergy. Ask the Expert, AAAAI, 2009.
Influenza Vaccines for the Future - NEJM, 2010 http://goo.gl/cPIgz
Tolerance to egg-containing baked foods (cake, bread) does not exclude the possibility of egg allergy (AAAAI Ask The Expert).


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