Food-Dependent Exercise-Induced Anaphylaxis (FDEIA)

Food-dependent exercise-induced anaphylaxis (FDEIA) is a special form of food allergy where a food-intake alone does not induce any symptoms. Anaphylaxis occurs only when triggering factors such as exercise or aspirin-intake are added after ingestion of the causative food.

The most frequent causative food in FDEIA in Japan is wheat. Both exercise and aspirin-intake facilitate allergen absorption from the gastrointestinal tract.

80% of the patients with wheat-induced FDEIA have IgE reacting to omega-5 gliadin and the remaining of the patients to high molecular weight glutenin (HMW-glutenin).

Food-dependent exercise-induced anaphylaxis (FDEIA)
Food-Dependent Exercise-Induced Anaphylaxis-Importance of Omega-5 Gliadin and HMW-Glutenin as Causative Antigens for Wheat-Dependent Exercise-Induced Anaphylaxis. Morita E, Matsuo H, Chinuki Y, Takahashi H, Dahlström J, Tanaka A. Allergol Int. 2009 Oct 25;58(4).
Image source:, public domain.
Exercise-induced anaphylaxis

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