Gardos channel is a protein "pump" that expels intracellular potassium when activated by calcium. Gardos channel causes dehydration of sickle erythrocytes, its inhibition may serve as an antisickling strategy. http://bit.ly/O15MF
Oral senicapoc, Gardos channel inhibitor, reduced the late asthmatic response to a challenge of inhaled allergen http://bit.ly/JuvyG
However, on 10/26/2009, Icagen Inc. said senicapoc failed the main goals of a midstage study, and it does not plan to keep developing the drug.
Icagen said that in the study of 69 patients randomly receiving either 40 mg of senicapoc daily or a placebo, the drug didn't improve the patients' exercise-induced asthma symptoms.
Icagen asthma drug senicapoc trial fails. Yahoo Finance, 2009.
Image source: Senicapoc. Wikipedia, public domain.