Dermatomyositis and polymyositis are disabling rheumatic diseases characterized by T cells infiltrating muscle tissue.
Patients with dermatomyositis and polymyositis were screened for frequency of CD4(+)CD28(null) and CD8(+)CD28(null) T cells in peripheral blood by flow cytometry.
Presence of these cells in inflamed muscle tissue from 13 of these patients was analyzed by three-color immunofluorescence microscopy.
Muscle-infiltrating T cells were predominantly CD4(+)CD28(null) and CD8(+)CD28(null) T cells in patients with dermatomyositis and polymyositis.
T Cell Infiltrates in the Muscles of Patients with Dermatomyositis and Polymyositis Are Dominated by CD28null T Cells. Authors: Fasth AE, Dastmalchi M, Rahbar A, Salomonsson S, Pandya JM, Lindroos E, Nennesmo I, Malmberg KJ, Söderberg-Nauclér C, Trollmo C, Lundberg IE, Malmström V. J Immunol. 2009 Sep 14.
Image source: X-Ray of the knee in a patient with dermatomyositis. Wikipedia,
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