Adverse effects of salmeterol monotherapy in asthma may be mediated via neurotrophin factor

Regular use of SABA/LABA has been associated with a paradoxical deterioration of airway hyper-responsiveness http://bit.ly/3klZpu


Salmeterol. Image source: Wikipedia, public domain.

Neurotrophin brain-derived neurotrophic factor (BDNF) is identified as a mediator of airway hyper-responsiveness in asthma.


Brain-derived neurotrophic factor. Image source: Wikipedia, Protien Data Bank, GNU Free Documentation License.

Adverse effects of salmeterol monotherapy in asthma may be mediated via brain-derived neurotrophic factor (BDNF). Salmeterol increased BDNF in serum and platelets. This increase was abolished by the addition of fluticasone.

Nerve growth factor (NGF) is an important mediator of airway hyper-responsiveness http://bit.ly/WixEs


Asthma classification and treatment for each stage. See more Allergy and Immunology mind maps here.