How to perform a food challenge for diagnosis of food allergy?
Food challenges, mind map diagram.
From Middleton's Allergy Principles and Practice:
Even the double-blind, placebo-controlled food challenge (DBPCFC) is not perfect, and false-positive and false-negative rates have been estimated to be between 1% and 3%.
Typical total doses administered during a food challenge: 8-10 g of the dry food, 100 mL of wet food, doubling the amounts for meat or fish.
Food challenge dosing scheme: divide the total challenge into 7 incremental doses: 1%, 4%, 10%, 15%, 20%, 25%, 25% of the total dose.
Example: Clinical efficacy and immune regulation with peanut oral immunotherapy. Jones SM et al. J Allergy Clin Immunol. 2009 Jul 2.
Food Allergy: A Short Review
Food Allergen Avoidance
Food challenges from Color atlas of allergic diseases By Martin Roecken, Gerhard Grevers, Walter Burgdorf:
Evaluation of food allergy from Manual of allergy and immunology By Daniel C. Adelman, Thomas B. Casale, Jonathan Corren: