How to perform a food challenge for diagnosis of food allergy?


Food challenges, mind map diagram.

From Middleton's Allergy Principles and Practice:

Even the double-blind, placebo-controlled food challenge (DBPCFC) is not perfect, and false-positive and false-negative rates have been estimated to be between 1% and 3%.

Typical total doses administered during a food challenge: 8-10 g of the dry food, 100 mL of wet food, doubling the amounts for meat or fish.

Food challenge dosing scheme: divide the total challenge into 7 incremental doses: 1%, 4%, 10%, 15%, 20%, 25%, 25% of the total dose.

Example: Clinical efficacy and immune regulation with peanut oral immunotherapy. Jones SM et al. J Allergy Clin Immunol. 2009 Jul 2.

References:
Food Allergy: A Short Review
Food Allergen Avoidance
Food Challenges

Food challenges from Color atlas of allergic diseases By Martin Roecken, Gerhard Grevers, Walter Burgdorf:



Evaluation of food allergy from Manual of allergy and immunology By Daniel C. Adelman, Thomas B. Casale, Jonathan Corren:

1 comment:

  1. I did not know that one can embed books so smoothly... good move!

    ReplyDelete

Blog Widget by LinkWithin