Mina, an IL-4 repressor, controls T helper type 2 bias


In this video, a T cell becomes activated when it interacts with a dedritic cell. This video is from: Janeway's Immunobiology, 7th Edition Murphy, Travers, & Walport. Source: Garland Science.

T helper type 2 bias is the propensity of naive CD4 T cells to differentiate into IL-4-secreting T(H)2 cells. Initially secreted IL-4 feeds back positively through IL-4 receptor and transcription factors STAT6 and GATA-3 to drive T(H)2 development. Mina, an IL-4 repressor, controls T helper type 2 bias http://bit.ly/Bdw9w

Mina is a member of the jumonji C (JmjC) protein family that represses the IL-4 promoter.

Jūmonji is a Japanese word meaning "cross" - genes encode nuclear proteins with a JmjC domain http://bit.ly/250TTq

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