Allergy and Immunology News of the Day

Health News of the Day is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day.

  • Regulatory T cells (Tregs) w transcription factor Foxp3 - 'master regulator' population with many levels of complexity. Foxp3 is a key regulator but insufficient and unnecessary to specify all aspects of the T regs lineage. Treg cell diversity: Distinct subphenotypes of Foxp3+ Treg cells are found in different anatomical locations

  • Developmental plasticity of Th17 and Treg cells - these cells are not "locked" into a final product

  • Asthmatic patients have decreased FOXP3 protein expression within their CD4+CD25high Treg cells. Inhaled glucocorticosteroids in asthmatics increase FOXP3 protein expression within the CD4+CD25high T-cell population

  • TLR choreography: Toll-like receptors (TLRs) must be deployed accurately and finely tuned. Tweaking a single amino acid in a TLR-trafficking molecule determined whether the signal was green or red. TLR7 and TLR9 recognize viral nucleic acids—RNA and DNA, respectively—in endolysosomes

  • IL-23 Promotes the Production of IL-17 by CD8 T Cells in the Absence of IL-12 and Type-I Interferons

  • Galvanizing allergies - late-phase allergic responses rely on the zinc transporter Znt5. Removing heavy metals, such as zinc, from mast cells disrupts their activation and blunts allergic responses

  • Accumulation of CD28 T cells, within the CD8 subset, is one of the most prominent changes associated with aging

  • CD95 (FAS) and BIM (BCL-2-interacting mediator of cell death) are 2 major regulators of apoptosis in T cell homeostasis

  • NKT cells turn ten - It has been 10 years since the first workshop on natural killer T cells

  • Antigen presentation: Basophils do it too

  • American Academy of Allergy, Asthma, and Immunology (AAAAI ) is actually blogging on their Facebook fan page:

  • Flickr: Pill montage

Image source:, public domain.

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