The relationship between plasma markers of inflammation and the incidence of chronic obstructive pulmonary disease (COPD) is still unclear. This population-based study explored whether raised levels of 5 inflammation-sensitive plasma proteins (ISPs) predicted hospital admissions for COPD during 25 years of follow-up.
Spirometric tests and measurements of five ISPs (fibrinogen, ceruloplasmin, 1-antitrypsin, haptoglobin, orosomucoid) were performed in 5247 healthy men from a Swedish city.
Ceruloplasmin (ferroxidase). Image source: Wikipedia, public domain.
Raised plasma ISP levels were associated with an increased incidence of COPD requiring hospitalisation.
Alpha globulins are a group of globular proteins in plasma, which are highly mobile in alkaline or electrically charged solutions:
Schematic representation of a protein electrophoresis gel. Image source: Wikipedia, public domain.
Alpha 1 globulins:
- Orosomucoid (acid glycoprotein)
Alpha 2 globulins:
Plasma markers of inflammation and incidence of hospitalisations for COPD: results from a population-based cohort study. G Engström1,2, N Segelstorm1, M Ekberg-Aronsson1, P M Nilsson1, F Lindgärde1 and C-G Löfdahl. Thorax 2009;64:211-215, 6 November 2008. doi:10.1136/thx.2008.102079.