Chronic idiopathic urticaria (CIU) impairs quality of life and the aim is to control symptoms but no consensus exists regarding how second-generation H(1)-antihistamines should be taken long-term: daily or only PRN.
Mast cells. Image source: Wikipedia.
Histamine structure. Image source: Wikipedia.
In a French study, the patients taking desloratadine daily showed significant improvements in scores for daily living activity, mood state, and social functioning vs PRN use.
The authors concluded that desloratadine 5 mg po is a better regimen than PRN for treatment of CIU.
Mind map diagram of chronic urticaria.
How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life. Grob JJ, Auquier P, Dreyfus I, Ortonne JP. Allergy. 2008 Dec 30.
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Patient response to different antihistamines will vary http://goo.gl/Q2PiV