Optimal dose for 5-grass pollen sublingual tablet immunotherapy: 300 IR

628 patients with grass pollen rhinoconjunctivitis were randomized in a double-blind, placebo-controlled trial conducted in Europe.

Patients received once-daily SLIT (Stallergenes, Antony, France) of 100IR, 300IR, 500IR or placebo, starting 4 months before grass pollen season and throughout the 2005 season.

Both 300IR and 500IR doses significantly reduced mean RTSS (Rhinoconjunctivitis Total Symptom Score) compared with placebo.

Specific immunoglobulin G4 increased significantly depending on the SLIT dose.

In conclusion, 300IR tablets represent the optimal dose.

Efficacy of Timothy grass allergy sublingual immunotherapy tablet: 37% symptoms reduction relative to placebo http://buff.ly/1G20dYB


Pollen-producing plants (weeds and trees) in Omaha, Nebraska. V. Dimov, M.D.

References:
Agreement of efficacy assessments for five-grass pollen sublingual tablet immunotherapy. Allergy. 2008 Dec 5. Didier A, Melac M, Montagut A, Lhéritier-Barrand M, Tabar A, Worm M.
Talking Points on Sublingual Immunotherapy (SLIT) for Physicians Practicing in the United States. ACAAI.
Pollen Role in Allergy and Asthma. Allergy Cases, 2008.

Timothy grass allergy immunotherapy tablets safe and effective in American children with allergic rhinitis http://goo.gl/tsKL4

Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults - it works. http://goo.gl/ePOFG
Sustained effects of grass pollen tablet: Combined symptom and medication scores demonstrated a 33% reduction, Allergy, 2011.

Interactive Allergy Map by Greer Labs. Click your state to find region-specific, common airborne allergens there.
Sublingual grass immunotherapy (SLIT): Confirmation of disease modification 2 years after 3 years of treatment. JACI, 2012.